Title
Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused <tex>$ApoE^{-/-}$</tex> mice Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused <tex>$ApoE^{-/-}$</tex> mice
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Pharmacology. Therapy
Source (journal)
Artery research
Volume/pages
8(2014) , p. 16-23
ISSN
1872-9312
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Purpose To explore new imaging techniques to elucidate some of the differences between both abdominal and ascending aortic aneurysms in the angiotensin II mouse model. Procedures Angiotensin II-infusing pumps were implanted in male ApoE−/− mice (n = 10). In vivo micro-CT, ultrasound and Positron emission tomography (PET) were used to follow up on aneurysm formation. Results We observed that the ascending aortic aneurysm gradually increased in size over the course of 49 days, while the abdominal aneurysm appeared much more suddenly in between scan times, or in some cases was not detectable at all on micro-CT. Diastolic backflow was detected from day 7 on in the ascending aorta, but not in the abdominal aorta of animals developing an aneurysm at the respective location. Finally PET 18F-FDG uptake was increased in both the ascending and the abdominal aneurysmatic aorta at day 14, but not at day 7. Conclusions Novel imaging techniques should be explored in-depth to come to a better understanding of the difference in morphology and hemodynamics between ascending and abdominal aneurysms in angiotensin II-infused ApoE−/− mice.
E-info
https://repository.uantwerpen.be/docman/iruaauth/d8503d/76a3a59addb.pdf
Handle