Title
Sample evaporation from pierceable cups : still an important source of analytical error
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Toronto, Ont. ,
Subject
Pharmacology. Therapy
Source (journal)
Clinical biochemistry. - Toronto, Ont.
Volume/pages
43(2010) :18 , p. 1464-1467
ISSN
0009-9120
ISI
000284520200018
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Background We illustrate the impact of sample evaporation on analytical results in laboratory practice and highlight preventive measures. Methods Plasma (n = 10) was analysed for glucose, Na+, HCO3− and calcium on six different sample configurations at 5 time points within 2 h. Results With time glucose, Na+ and calcium values increased and HCO3− values decreased in a clinically significant way. Conclusions Analytical error due to evaporation may be significant, but can be reduced with optimal sample handling. A pierceable cover does not prevent loss of HCO3−.
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