Sample evaporation from pierceable cups : still an important source of analytical errorSample evaporation from pierceable cups : still an important source of analytical error
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
2010Toronto, Ont., 2010
Clinical biochemistry. - Toronto, Ont.
43(2010):18, p. 1464-1467
Background We illustrate the impact of sample evaporation on analytical results in laboratory practice and highlight preventive measures. Methods Plasma (n = 10) was analysed for glucose, Na+, HCO3− and calcium on six different sample configurations at 5 time points within 2 h. Results With time glucose, Na+ and calcium values increased and HCO3− values decreased in a clinically significant way. Conclusions Analytical error due to evaporation may be significant, but can be reduced with optimal sample handling. A pierceable cover does not prevent loss of HCO3−.