Publication
Title
Plasma adiponectin level is inversely correlated with albuminuria in overweight and obese nondiabetic individuals
Author
Abstract
Objective. To explore the relationship between adiponectin and albuminuria in a large group of overweight and obese nondiabetic individuals after controlling for potential confounders. Material and Methods. Detailed anthropometiy, computed tomography-measured visceral abdominal adipose tissue, 24-h albuminuria, adiponectin and a series of biochemical parameters were assessed. Four hundred forty patients, predominantly of Caucasian origin, were included (80.2% female). A multiple linear regression model was developed, with albuminuria as the dependent variable and potential predictors as independent variables. Results. The mean age was 40 +/- 13 years, the mean body mass index was 35.7 +/- 6.6 kg/m(2), and the median visceral abdominal adipose tissue was 142.4 (92.3-194.0) cm(2). 10.9% of subjects exhibited microalbuminuria. The median adiponectin level was 9.08 (6.23-12.94) mu g/ml, and the median fasting serum glucose level was 83 (77-89) mg/dl. The strongest significant univariate correlations with albuminuria were visceral abdominal adipose tissue (r = 0.258, p < 0.001), adiponectin (r = -0.265, p < 0.001), waist circumference (r = 0.250, p < 0.001), waist-to-hip ratio (r = 0.236, p < 0.001) and high-density lipoprotein cholesterol (r = -0.211, p < 0.001). The multiple linear regression model revealed a significant positive independent correlation between visceral abdominal adipose tissue and albuminuria (r = 0.134, p = 0.033), between fasting glucose levels and albuminuria (r = 0.390, p = 0.029) and between gender and albuminuria (r = 0.107, p = 0.038). A significant independent negative correlation was identified between adiponectin and albuminuria (r = -0.255, p = 0.022). Conclusions. We observed an independent inverse relationship between adiponectin and albuminuria in overweight and obese nondiabetic individuals. Further investigations are needed to confirm this finding and to clarify whether adiponectin is a risk marker or plays a causative role in developing obesity-induced nephropathy. (C) 2013 Elsevier Inc. All rights reserved.
Language
English
Source (journal)
Metabolism: clinical and experimental. - New York
Publication
New York : 2013
ISSN
0026-0495
Volume/pages
62:11(2013), p. 1570-1576
ISI
000330924500008
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.04.2014
Last edited 29.05.2017
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