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Title
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Synthesis of -aziridino -amino acid derivatives and their stereoselective ring transformation to 2-(aminomethyl)-1-aminocyclopropanecarboxylic acid derivatives
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Author
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Abstract
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| 1-Benzyl-2-(bromomethyl)aziridine was successfully substituted with protected glycine esters to afford alkyl 3-(N-benzylaziridin-2-yl)-2-aminopropanoates, as constrained heterocyclic diamino acid derivatives, in good isolated yields. These new aziridines proved to be excellent building blocks for ring transformation to the corresponding stereochemically defined 2-(aminomethyl)-1-aminocyclopropanecarboxylic acid derivatives, including methyl esters, piperidyl amides, and free carboxylic acids. |
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Language
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English
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Source (journal)
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European journal of organic chemistry. - Weinheim, 1998, currens
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Publication
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Weinheim
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2014
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ISSN
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1434-193X
[print]
1099-0690
[online]
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DOI
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10.1002/EJOC.201301030
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Volume/pages
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2014
:6
(2014)
, p. 1220-1226
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ISI
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000331209600014
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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