Publication
Title
Synthesis of -aziridino -amino acid derivatives and their stereoselective ring transformation to 2-(aminomethyl)-1-aminocyclopropanecarboxylic acid derivatives
Author
Abstract
1-Benzyl-2-(bromomethyl)aziridine was successfully substituted with protected glycine esters to afford alkyl 3-(N-benzylaziridin-2-yl)-2-aminopropanoates, as constrained heterocyclic diamino acid derivatives, in good isolated yields. These new aziridines proved to be excellent building blocks for ring transformation to the corresponding stereochemically defined 2-(aminomethyl)-1-aminocyclopropanecarboxylic acid derivatives, including methyl esters, piperidyl amides, and free carboxylic acids.
Language
English
Source (journal)
European journal of organic chemistry. - Weinheim
Publication
Weinheim : 2014
ISSN
1434-193X
Volume/pages
2014:6(2014), p. 1220-1226
ISI
000331209600014
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.04.2014
Last edited 17.05.2017
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