Normative values for corneal densitometry analysis by Scheimpflug optical assessmentNormative values for corneal densitometry analysis by Scheimpflug optical assessment
Faculty of Medicine and Health Sciences
Translational Neurosciences (TNW)
2014St. Louis, Mo., 2014
Investigative ophthalmology and visual science. - St. Louis, Mo.
55(2014):1, p. 162-168
University of Antwerp
PURPOSE. To describe the normative data for corneal Scheimpflug densitometry based on a cohort of normal participants. METHODS. A total of 445 healthy participants were recruited for assessment (794 eyes). Left and right eyes were considered separately. All participants were assessed using the corneal densitometry analysis add-on to the standard software of the Oculus Pentacam. Densitometry measurements were obtained and expressed in standardized grayscale units (GSU). RESULTS. All participants were Caucasian; 42% were male and 58% were female. The mean age was 48.0 +/- 15.3 years (range, 20.2-84.2 years). Mean corneal densitometry over the 12-mm-diameter area was 19.74 +/- 3.89 GSU. When divided by radial zone, densitometry values were lowest in the central zone (16.76 +/- 1.87 GSU) and highest in the periphery (27.36 +/- 7.47 GSU). There was no difference between central zone and the surrounding 2- to 6-mm annulus (P > 0.05), though the 6- to 10-mm and the 10- to 12-mm zones displayed higher densitometry values (P < 0.001). When divided by depth, the anterior layer displayed the highest densitometry reading of 25.81 +/- 5.14 GSU, which was significantly higher than that of both the central (P < 0.001) and the posterior layers (P < 0.001). Changes in corneal densitometry were correlated with age, though not within the central 6-mm-diameter ring. No sex difference was seen within the cohort. CONCLUSIONS. This add-on to the standard imaging software allows rapid and objective assessment of the corneal densitometry. We provide normative data that may be used as a reference facilitating research and complementing clinical examination.