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Title
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Alpha-synuclein repeat variants and survival in Parkinson's disease
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Author
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Institution/Organisation
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Genetic Epidemiology of Parkinson's Disease Consortium
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Abstract
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| Objectives To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed. |
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Language
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English
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Source (journal)
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Movement disorders: video, videotape supplements. - New York
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Publication
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New York
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2014
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ISSN
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0885-3185
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DOI
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10.1002/MDS.25841
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Volume/pages
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29
:8
(2014)
, p. 1053-1057
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ISI
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000340089300015
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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