Title
Predictors of mortality among tuberculosis-HIV-coinfected persons in Southwest Ethiopia : a casecontrol studyPredictors of mortality among tuberculosis-HIV-coinfected persons in Southwest Ethiopia : a casecontrol study
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Epidemiology and social medicine (ESOC)
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Journal of the International Association of Providers of AIDS Care (JIAPAC)
Volume/pages
(2013)
ISSN
2325-9574
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB-HIV-coinfected patients. Methods: We conducted an unmatched casecontrol study among a cohort of TB-HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB-HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB-HIV-coinfected patients who were alive during the end of the follow-up period. Results: Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB-HIV-infected patients. Conclusion: Mortality among TB-HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.
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