Title
Lexicographical dynamic goal programming approach to arobust design optimization within the pharmaceutical environment Lexicographical dynamic goal programming approach to arobust design optimization within the pharmaceutical environment
Author
Faculty/Department
Faculty of Applied Economics
Publication type
article
Publication
Amsterdam ,
Subject
Economics
Source (journal)
European journal of operational research. - Amsterdam
Volume/pages
229(2013) , p. 505-517
ISSN
0377-2217
ISI
000319307600022
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The primary objective ofthis paper istodevelop anew robust design (RD)optimization procedure based on alexicographical dynamic goal programming (LDGP)approach for implementing time-series based multi-responses, while the conve ntional experimental design formats and frameworks may implement static responses. First,aparameter estimation method for time-dependent pharmaceutical responses (i.e., drug release and gelati onkinetics)isproposed using the dual response estimation concept that separately estimates the response functions ofthe mean and variance,asapart ofresponse surface method. Second,amulti-objective RDoptimization model using the estimated response functions ofboth the process mean and variance isproposed byincorpor ating atime-series components within adynamic modeling environment. Finally,apharmaceutical case study associated with ageneric drug development process is conducted for verificationpurposes.Based onthe case study results,weconclude that the pro- posed LDGP approach effectively provides the optimal drug formulations with significantlysmall biases and MSE values,compared toother models.
E-info
https://repository.uantwerpen.be/docman/iruaauth/01fb0d/c63b6d17f89.pdf
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319307600022&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319307600022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319307600022&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle