Title
Vitamin B12 in pregnancy : maternal and fetal/neonatal effectsA review
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Irvine, CA :Scientific Research Pub ,
Subject
Human medicine
Source (journal)
Open journal of obstetrics and gynecology. - Irvine, CA, 2011, currens
Volume/pages
3(2013) :7 , p. 599-602
ISSN
2160-8792
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Vitamin B12 maintains normal folate metabolism which is essential for cell multiplication during pregnancy. No good data are available on what constitutes vitamin B12 deficiency in pregnancy, nevertheless vitamin B12 deficiency is frequently reported in pregnancy due to inadequate dietary intake of vitamin B12 and a physiological decline of maternal vitamin B12 concentrations. This decline can be explained by the increased maternal metabolic rate and active transport by the placenta to the fetus. If the mother is deficient during pregnancy, the baby may have low serum vitamin B12 concentrations at birth [1]. Vitamin B12 deficiency during pregnancy is associated with preeclampsia, fetal growth restriction, preterm labor, neural tube defects, neonatal megaloblastic anemia and neonatal neurological symptoms. It has been suggested to improve vitamin B12 status of women in the periconceptional period by supplementation of vitamin B12, but no randomized studies on the outcome of such supplementation have been published.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/49e065/3426f815.pdf
Handle