Publication
Title
Laser microprobe mass spectrometry of platinum in dog kidney after cisplatin adminstration
Author
Abstract
By means of laser microprobe mass analysis (LAMMA) platinum was detected in the renal proximal tubular cells of a dog that had been intravenously adminstered the antitumor drug cisplatin (5 mg per kg body weight). No definite subcellular localization of the heavy metal was obtained. Sample prparation and analytical features are examined to increase spatial resolution of analysis while maintaining sufficient detection efficiency. The LAMMA method is destructive, but the amount and type of evaporated material can readily be determined when using LAMMA in combination with transmission electron microscopy. Instrumental optimization and standardization of mass signals is possible by using platinum-loaded, ion chelating resin beads embedded and sectioned with the tissue.
Language
English
Source (journal)
Biomedical mass spectrometry. - London, 1974 - 1985
Publication
London : 1984
ISSN
0306-042X
Volume/pages
11:4(1984), p. 159-163
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Record
Identification
Creation 07.05.2014
Last edited 22.11.2016
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