Title
Ultrastructural localization of aluminum in patients with dialysis-associated osteomalacia Ultrastructural localization of aluminum in patients with dialysis-associated osteomalacia
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Winston-Salem, N.C. ,
Subject
Chemistry
Pharmacology. Therapy
Human medicine
Source (journal)
Clinical chemistry : international journal of laboratory medicine and molecular diagnostics / American Association of Clinical Chemists. - Winston-Salem, N.C., 1955, currens
Volume/pages
30(1984) :5 , p. 763-768
ISSN
0009-9147
1530-8561
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Using laser microprobe mass analysis, we studied the ultrastructural localization of aluminum in liver and bone tissue of chronic-hemodialysis patients with proven aluminum-induced osteomalacia. In the liver, aluminum was observed to be almost exclusively associated with iron. Detectable aluminum and large amounts of iron were found in lysosomes of both hepatocytes and Kupffer cells. In bone, aluminum was localized at the osteoid/calcified-bone interface and also was associated with iron in some cases.
E-info
https://repository.uantwerpen.be/docman/iruaauth/615c2e/b0ad70b612a.pdf
Handle