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Title
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Skin penetration of minerals in psoriatics and guinea-pigs bathing in hypertonic salt solutions
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Author
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Abstract
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| Penetration of electrolytes through the human skin was measured in healthy volunteers and in psoriatic patients after bathing in the Dead-Sea or in simulated bath-salt solutions. Significant increases in the levels of serum Br, Rb, Ca and Zn were noticed only in the psoriatic patients after daily bathing in the Dead-Sea for a 4-week regimen. Guinea-pigs bathed in simulated Dead-Sea bath-salt solutions containing radionuclides of Ca, Mg, K and Br. Traces of each radionuclide were detected in the blood and in some internal organs after 60 minutes of bathing. The radionuclides showed a physiological pattern in their organ distribution. Even though the whole investigation was carried out in hypertonic solutions, there is a definite penetration of salts through healthy (human and guinea-pigs) and damaged (psoriatic) epidermis. This finding suggests that improvement of the psoriatic condition after bathing in the Dead-Sea, may be partly attributed (in addition to ultraviolet irradiation) to the minerals' effect on the psoriatic skin. |
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Language
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English
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Source (journal)
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Pharmacological research communications. - London
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Publication
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London
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1985
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ISSN
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0031-6989
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DOI
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10.1016/0031-6989(85)90123-7
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Volume/pages
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17
:6
(1985)
, p. 501-512
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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