Title
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Increased erythrocyte glutathione peroxidase activity in psoriatics consuming high-selenium drinking water at the dead-sea psoriasis treatment center
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Author
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Abstract
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Erythrocyte selenium-dependent glutathione peroxidase activity was measured in psoriatic Danes, before and after their four-week balneological therapy at the Ein-Bokek International Psoriasis Treatment Center, on the Dead-Sea shore in Israel. The drinking water in Ein-Bokek was found to be rich in selenium, a trace element with anticarcinogenic properties and of great importance in human nutrition and health. The most reliable biological parameter for increase in selenium bioavailability is the erythrocytes' glutathione-peroxidase activity. As psoriasis is a proliferative skin disease, the activity of this enzyme was assayed in 35 psoriatic Danes and in 25 long-term local hotel workers, as well as in 34 volunteers drinking low-selenium water. The glutathione peroxidase activity in the psoriatic patients increased significantly during their four-week stay in Ein-Bokek. Erythrocyte glutathione peroxidase activity in the hotel workers was 50% higher than that in the healthy volunteers consuming low-selenium water. A possible role of selenium in psoriasis is suggested. |
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Language
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English
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Source (journal)
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Pharmacological research communications. - London
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Publication
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London
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1985
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ISSN
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0031-6989
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DOI
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10.1016/0031-6989(85)90083-9
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Volume/pages
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17
:5
(1985)
, p. 479-488
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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