Title
Use of laser microprobe mass analysis (LAMMA) for localizing multiple elements in soft and hard tissues Use of laser microprobe mass analysis (LAMMA) for localizing multiple elements in soft and hard tissues
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Chemistry
Human medicine
Source (journal)
Biological trace element research. - London
Volume/pages
13(1987) , p. 397-416
ISSN
0163-4984
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The potential of laser microprobe mass analysis (LAMMA) as a sensitive microanalytical technique was explored in applications relevant to nephrology. Aluminum and associated elements, such as iron, were localized in fresh tissue biopsies obtained from uremic patients treatment by chronic hemodialysis. The LAMMA was applied to serum, liver, bone, and parathyroid glands of such patients. In addition, we used LAMMA to evaluate the specificity and sensitivity of routine histochemistry, in particular on human bone sections stained by the aluminon method. The high, multielemental sensitivity and molecular microprobe potential of LAMMA established important advantages over other microchemical methods forin situ analysis at the micron level in histological sections.
Handle