Title
Ultrastructural localization of aluminium in liver of aluminium maltol-treated rabbits by laser microprobe mass analysis
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Chemistry
Source (journal)
Biomedical and environmental mass spectrometry. - London, 1986 - 1990
Volume/pages
18(1989) :8 , p. 598-602
ISSN
0887-6134
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
By means of laser microprobe mass analysis (LAMMA), we have studied the ultrastructural localization of aluminium in livers of aluminium maltol-treated rabbits. This animal model was developed to study long-term aluminium toxicity using systemic (intravenous) administration of aluminium. We could only detect aluminium in electron-dense inclusion bodies found in large, sometimes multinucleated cells. These results prove that the actual observation of aluminium deposits in liver with LAMMA gives more information than bulk analysis and can be very useful to explore mechanisms of toxicity.
Handle