Title
Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in Saudi and Yemeni traditional medicine Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in Saudi and Yemeni traditional medicine
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Oxford ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Evidence-based complementary and alternative medicine. - Oxford
Volume/pages
(2014) , 7 p.
ISSN
1741-427X
Article Reference
905639
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The antiplasmodial, antileishmanial, and antitrypanosomal activity of twenty-five medicinal plants distributed in Saudi Arabia and Yemen was evaluated. The plants were extracted withmethanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi, and free trypomastigotes of T. brucei. To assess selectivity, cytotoxicity was determined on MRC-5 cells. Criteria for activity were an IC50 < 10&#120583;g/mL and high selectivity (SI). Seven plants showed interesting antiprotozoal activity in one or more models. Extracts of Caralluma penicillata and Acalypha ciliata showed fairly good activity against P. falciparum with IC50 of 6.7 and 10.8 &#120583;g/mL and adequate selectivity (SI > 9.6 and > 5.9). Interesting activity against L. infantum was obtained with Verbascum bottae (IC50 of 3.2 &#120583;g/mL, SI 10.2) and Solanum glabratum (IC50 8.1 &#120583;g/mL, SI 3.4).The extracts of C. penicillata, Leucas virgata, Loranthus regularis, and V. bottae exhibited moderate activity against T. brucei (IC50 8.5, 8.1, 8.3, and 2.3 &#120583;g/mL; SI > 7.6, 7.7, 4.3, and > 14.1).These results partly support the
Full text (open access)
https://repository.uantwerpen.be/docman/irua/b0d173/9dfc3b6c.pdf
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