Publication
Title
Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in Saudi and Yemeni traditional medicine
Author
Abstract
The antiplasmodial, antileishmanial, and antitrypanosomal activity of twenty-five medicinal plants distributed in Saudi Arabia and Yemen was evaluated. The plants were extracted withmethanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi, and free trypomastigotes of T. brucei. To assess selectivity, cytotoxicity was determined on MRC-5 cells. Criteria for activity were an IC50 < 10𝜇g/mL and high selectivity (SI). Seven plants showed interesting antiprotozoal activity in one or more models. Extracts of Caralluma penicillata and Acalypha ciliata showed fairly good activity against P. falciparum with IC50 of 6.7 and 10.8 𝜇g/mL and adequate selectivity (SI > 9.6 and > 5.9). Interesting activity against L. infantum was obtained with Verbascum bottae (IC50 of 3.2 𝜇g/mL, SI 10.2) and Solanum glabratum (IC50 8.1 𝜇g/mL, SI 3.4).The extracts of C. penicillata, Leucas virgata, Loranthus regularis, and V. bottae exhibited moderate activity against T. brucei (IC50 8.5, 8.1, 8.3, and 2.3 𝜇g/mL; SI > 7.6, 7.7, 4.3, and > 14.1).These results partly support the
Language
English
Source (journal)
Evidence-based complementary and alternative medicine. - Oxford
Publication
Oxford : 2014
ISSN
1741-427X
Volume/pages
(2014), 7 p.
Article Reference
905639
ISI
000336617600001
Medium
E-only publicatie
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 28.05.2014
Last edited 17.11.2017
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