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Title
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Strategies to manage hepatitis C virus (HCV) disease burden
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Author
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Abstract
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| The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 35 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical. |
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Language
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English
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Source (journal)
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Journal of viral hepatitis. - Oxford
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Publication
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Oxford
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2014
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ISSN
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1352-0504
[print]
1365-2893
[online]
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DOI
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10.1111/JVH.12249
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Volume/pages
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21
(2014)
, p. 60-89
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ISI
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000333893200004
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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