Title
Implementation of genomic arrays in prenatal diagnosis : the Belgian approach to meet the challengesImplementation of genomic arrays in prenatal diagnosis : the Belgian approach to meet the challenges
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Medical Genetics (MEDGEN)
VIB DMG - Peripheral Neuropathies Group
Cognitive Genetics (COGNET)
Publication type
article
Publication
Paris,
Subject
Human medicine
Source (journal)
European journal of medical genetics. - Paris
Volume/pages
57(2014):4, p. 151-156
ISSN
1769-7212
ISI
000334765800006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
After their successful introduction in postnatal testing, genome-wide arrays are now rapidly replacing conventional karyotyping in prenatal diagnostics. While previous studies have demonstrated the advantages of this method, we are confronted with difficulties regarding the technology and the ethical dilemmas inherent to genomic arrays. These include indication for testing, array design, interpretation of variants and how to deal with variants of unknown significance and incidental findings. The experiences with these issues reported in the literature are most often from single centres. Here, we report on a national consensus approach how microarray is implemented in all genetic centres in Belgium. These recommendations are subjected to constant re-evaluation based on our growing experience and can serve as a useful tool for those involved in prenatal diagnosis. (C) 2014 Elsevier Masson SAS. All rights reserved.
E-info
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