Title
Polarity specific suppression effects of transcranial direct current stimulation for tinnitus Polarity specific suppression effects of transcranial direct current stimulation for tinnitus
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York :Hindawi Pub. Corp ,
Subject
Human medicine
Source (journal)
Neural plasticity. - New York, 1989, currens
Volume/pages
(2014) , p. 1-8
ISSN
2090-5904
Article Reference
930860
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Tinnitus is the perception of a sound in the absence of an external auditory stimulus and affects 10-15% of the Western population. Previous studies have demonstrated the therapeutic effect of anodal transcranial direct current stimulation (tDCS) over the left auditory cortex on tinnitus loudness, but the effect of this presumed excitatory stimulation contradicts with the underlying pathophysiological model of tinnitus. Therefore, we included 175 patients with chronic tinnitus to study polarity specific effects of a single tDCS session over the auditory cortex (39 anodal, 136 cathodal). To assess the effect of treatment, we used the numeric rating scale for tinnitus loudness and annoyance. Statistical analysis demonstrated a significant main effect for tinnitus loudness and annoyance, but for tinnitus annoyance anodal stimulation has a significantly more pronounced effect than cathodal stimulation. We hypothesize that the suppressive effect of tDCS on tinnitus loudness may be attributed to a disrupting effect of ongoing neural hyperactivity, independent of the inhibitory or excitatory effects and that the reduction of annoyance may be induced by influencing adjacent or functionally connected brain areas involved in the tinnitus related distress network. Further research is required to explain why only anodal stimulation has a suppressive effect on tinnitus annoyance.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/c492e6/7641.pdf
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