Title
In vitro and in vivo activity of major constituents from **Pluchea carolinensis** against **Leishmania amazonensis** In vitro and in vivo activity of major constituents from **Pluchea carolinensis** against **Leishmania amazonensis**
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Berlin ,
Subject
Biology
Pharmacology. Therapy
Human medicine
Source (journal)
Parasitology research. - Berlin
Volume/pages
113(2014) :8 , p. 2925-2932
ISSN
0932-0113
ISI
000339965300018
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The search for new therapeutic agents from natural sources has been a constant for the treatment of diseases such as leishmaniasis. Herein, in vitro and in vivo pharmacological activities of pure major phenolic constituents (caffeic acid, chlorogenic acid, ferulic acid, quercetin, and rosmarinic acid) from Pluchea carolinensis against Leishmania amazonensis are presented. Pure compounds showed inhibitory activity against promastigotes (IC50 = 0.20.9 μg/mL) and intracellular amastigotes (IC50 = 1.32.9 μg/mL). Four of them were selected after testing against macrophages of BALB/c mice: caffeic acid, ferulic acid, quercetin, and rosmarinic acid, with selective indices of 11, 17, 10, and 20, respectively. Ferulic acid, rosmarinic acid, and caffeic acid controlled lesion size development and parasite burden in footpads from BALB/c experimentally infected mice, after five injections of compounds by intralesional route at 30 mg/kg every 4 days. Pure compounds from P. carolinensis demonstrated antileishmanial properties.
E-info
https://repository.uantwerpen.be/docman/iruaauth/58c066/db864d98ec4.pdf
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