Title
Animal models of invasive aspergillosis for drug discovery Animal models of invasive aspergillosis for drug discovery
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Oxford :Elsevier sci ltd ,
Subject
Biology
Pharmacology. Therapy
Veterinary medicine
Human medicine
Source (journal)
Drug discovery today. - London
Volume/pages
19(2014) :9 , p. 1380-1386
ISSN
1359-6446
ISI
000342604100012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Although Aspergillus infections pose a growing threat to immunocompromised individuals, the limited range of existing drugs does not allow efficient management of invasive aspergillosis. Moreover, drug resistance is becoming increasingly common. Given that drug discovery relies on high-quality animal studies, careful design of in vivo models for invasive aspergillosis could facilitate the identification of novel antifungals. In this review, we discuss key aspects of animal models for invasive aspergillosis, covering laboratory animal species, immune modulation, inoculation routes, Aspergillus strains, treatment strategies and efficacy assessment, to enable the reader to tailor specific protocols for different types of preclinical antifungal evaluation study.
E-info
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