Publication
Title
Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls
Author
Abstract
Background aims Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS). Methods We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls. Results Except for an increase in the number of C-C chemokine receptor 7expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells. Conclusions Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.
Language
English
Source (journal)
Cytotherapy
Publication
2014
ISSN
1465-3249
Volume/pages
16:7(2014), p. 1024-1030
ISI
000337655500015
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 18.06.2014
Last edited 20.05.2017
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