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Title
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Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls
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Author
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Abstract
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| Background aims Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS). Methods We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls. Results Except for an increase in the number of C-C chemokine receptor 7expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells. Conclusions Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS. |
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Language
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English
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Source (journal)
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Cytotherapy
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Publication
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2014
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ISSN
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1465-3249
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DOI
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10.1016/J.JCYT.2014.02.016
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Volume/pages
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16
:7
(2014)
, p. 1024-1030
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ISI
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000337655500015
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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