Title
Clinical use of dendritic cells for cancer therapy Clinical use of dendritic cells for cancer therapy
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New york :Elsevier science inc ,
Subject
Human medicine
Source (journal)
The lancet oncology. - London
Volume/pages
15(2014) :7 , p. E257-E267
ISSN
1470-2045
ISI
000336505900021
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Since the mid-1990s, dendritic cells have been used in clinical trials as cellular mediators for therapeutic vaccination of patients with cancer. Dendritic cell-based immunotherapy is safe and can induce antitumour immunity, even in patients with advanced disease. However, clinical responses have been disappointing, with classic objective tumour response rates rarely exceeding 15%. Paradoxically, findings from emerging research indicate that dendritic cell-based vaccination might improve survival, advocating implementation of alternative endpoints to assess the true clinical potency of dendritic cell-based vaccination. We review the clinical effectiveness of dendritic cell-based vaccine therapy in melanoma, prostate cancer, malignant glioma, and renal cell carcinoma, and summarise the most important lessons from almost two decades of clinical studies of dendritic cell-based immunotherapy in these malignant disorders. We also address how the specialty is evolving, and which new therapeutic concepts are being translated into clinical trials to leverage the clinical effectiveness of dendritic cell-based cancer immunotherapy. Specifically, we discuss two main trends: the implementation of the next-generation dendritic cell vaccines that have improved immunogenicity, and the emerging paradigm of combination of dendritic cell vaccination with other cancer therapies.
E-info
https://repository.uantwerpen.be/docman/iruaauth/c5c5f5/fc0847e4bb4.pdf
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