Overview of the current state-of-the-art for bioaccumulation models in marine mammals
Faculty of Sciences. Biology
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Toxics. - 2013, currens
, p. 226-246
University of Antwerp
Information regarding the (toxico)kinetics of a chemical in organisms can be integrated in mathematical equations thereby creating bioaccumulation models. Such models can reconstruct previous exposure scenarios, provide a framework for current exposures and predict future situations. As such, they are gaining in popularity for risk assessment purposes. Since marine mammals are protected, the modeling process is different and more difficult to complete than for typical model organisms, such as rodents. This review will therefore discuss the currently available models for marine mammals, address statistical issues and knowledge gaps, highlight future perspectives and provide general dos and donts.