Title
Extremely elevated cerebrospinal fluid protein levels in a child with neurologic symptoms : beware of haemophagocytic lymphohistiocytosis Extremely elevated cerebrospinal fluid protein levels in a child with neurologic symptoms : beware of haemophagocytic lymphohistiocytosis
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
European journal of paediatric neurology. - London
Volume/pages
18(2014) :3 , p. 427-429
ISSN
1090-3798
ISI
000336695500027
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Neurologic symptoms can be the initial manifestation of haemophagocytic lymphohistiocytosis (HLH). In this case study, we present a 3-year old boy with a clinical picture of encephalitis, a cerebrospinal fluid (CSF) protein level up to 1165 mg/dl and diffuse cerebral MRI abnormalities. The diagnosis of HLH was established only 6 weeks after initial presentation. The boy recovered after HLH therapy with persisting mild cognitive defects. Genetic investigation demonstrated X-linked lymphoproliferative disease (XLP) as the underlying cause of HLH. The extremely elevated protein level in CSF in this case has not yet been reported in patients with HLH. (C) 2013 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
E-info
https://repository.uantwerpen.be/docman/iruaauth/190612/4987737.pdf
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