Title
Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substances Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substances
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Oxford :Elsevier sci ltd ,
Subject
Chemistry
Source (journal)
Trends in analytical chemistry. - Amsterdam
Volume/pages
57(2014) , p. 107-117
ISSN
0165-9936
ISI
000336711700028
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In the past decade, an increasing number of new psychoactive substances (NPSs) were introduced on the drug markets through various modes of distribution, including the and smart shops. Recent reports on their adverse effects produced alarming social concern. Detection of such NPSs is a challenge due to their quick introduction, creating a constantly moving analytical target. Modern analytical chemistry can give a rapid, efficient answer by detecting and identifying the compounds responsible for harmful effects. High-resolution mass spectrometry (HRMS) is a valuable analytical tool, as it provides sensitive, full-spectrum MS data with high mass resolution and mass accuracy. We evaluate different analytical strategies based on time-of-flight MS for screening and identifying NPSs. These strategies include unbiased non-target screening, target screening, and biased non-target screening. We explain and demonstrate these approaches with examples of NPSs investigated in herbal blends, pills, powders, drinkable solutions and truffles. (C) 2014 Elsevier Ltd. All rights reserved.
E-info
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