Publication
Title
Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substances
Author
Abstract
In the past decade, an increasing number of new psychoactive substances (NPSs) were introduced on the drug markets through various modes of distribution, including the and smart shops. Recent reports on their adverse effects produced alarming social concern. Detection of such NPSs is a challenge due to their quick introduction, creating a constantly moving analytical target. Modern analytical chemistry can give a rapid, efficient answer by detecting and identifying the compounds responsible for harmful effects. High-resolution mass spectrometry (HRMS) is a valuable analytical tool, as it provides sensitive, full-spectrum MS data with high mass resolution and mass accuracy. We evaluate different analytical strategies based on time-of-flight MS for screening and identifying NPSs. These strategies include unbiased non-target screening, target screening, and biased non-target screening. We explain and demonstrate these approaches with examples of NPSs investigated in herbal blends, pills, powders, drinkable solutions and truffles. (C) 2014 Elsevier Ltd. All rights reserved.
Language
English
Source (journal)
Trends in analytical chemistry. - Amsterdam
Publication
Oxford : Elsevier sci ltd, 2014
ISSN
0165-9936
Volume/pages
57(2014), p. 107-117
ISI
000336711700028
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 03.07.2014
Last edited 19.06.2017
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