Primary intraosseous manifestation of Rosai-Dorfman disease: 2 cases and review of literaturePrimary intraosseous manifestation of Rosai-Dorfman disease: 2 cases and review of literature
Faculty of Medicine and Health Sciences
97(2014), p. 84-89
University of Antwerp
Rosai-Dorman disease (RDD) is a rare disorder of proliferative histiocytes with an unknown etiology. It is also known as sinus histiocytosis with massive lymphadenopathy. Most patients present with painless cervical lymphadenopathy due to accumulation of histiocytes in the lymph nodes, often in conjunction with fever, elevated leukocyte count and erythrocyte sedimentation rate. Isolated skeletal involvement is very rare.