Publication
Title
Reference curve for the first-year growth response to growth hormone treatment in prepubertal children with idiopathic growth hormone deficiency : validation of the KIGS first-year growth response curve using the Belgian register for the study of growth and puberty problems
Author
Abstract
Background: Comparing observed and expected growth after first-year growth hormone (GH) therapy is useful for identifying a poor growth response to GH. Aim: To generate a first-year, age-specific growth response reference curve for prepubertal Belgian children with idiopathic growth hormone deficiency (iGHD) treated with a standard weight-adjusted GH dose and to compare this national reference with the response references derived from KIGS. Subjects and Methods: First-year height data of 357 prepubertal children (240 males) with iGHD were analyzed. Smooth reference curves of first-year height velocity (HV) in relation to age were created. Differences with the KIGS targets were evaluated after z-score transformation. Results: The observed first-year HVs were log-normal distributed by age and decreased significantly with age (p < 0.001). No GH dose or gender effect was observed (p = 0.5). Distance to target height, severity of GHD and occurrence of multiple pituitary hormone deficiencies had a positive effect (p < 0.01) on the calculated HV SDS. When applying the KIGS targets for severe iGHD, mean HV SDS was close to zero (-0.09 +/- 0.84). Conclusion: The developed age-specific growth response curves enable rapid identification of poor response to first-year GH treatment in prepubertal iGHD children. Our results validate the published growth targets derived from the KIGS database. (C) 2014 S. Karger AG, Basel
Language
English
Source (journal)
Hormone research in paediatrics. - Basel
Publication
Basel : Karger, 2014
ISSN
1663-2818
Volume/pages
81:5(2014), p. 343-349
ISI
000337797800008
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 28.08.2014
Last edited 18.06.2017
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