|
Title
|
|
|
|
Reference curve for the first-year growth response to growth hormone treatment in prepubertal children with idiopathic growth hormone deficiency : validation of the KIGS first-year growth response curve using the Belgian register for the study of growth and puberty problems
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Background: Comparing observed and expected growth after first-year growth hormone (GH) therapy is useful for identifying a poor growth response to GH. Aim: To generate a first-year, age-specific growth response reference curve for prepubertal Belgian children with idiopathic growth hormone deficiency (iGHD) treated with a standard weight-adjusted GH dose and to compare this national reference with the response references derived from KIGS. Subjects and Methods: First-year height data of 357 prepubertal children (240 males) with iGHD were analyzed. Smooth reference curves of first-year height velocity (HV) in relation to age were created. Differences with the KIGS targets were evaluated after z-score transformation. Results: The observed first-year HVs were log-normal distributed by age and decreased significantly with age (p < 0.001). No GH dose or gender effect was observed (p = 0.5). Distance to target height, severity of GHD and occurrence of multiple pituitary hormone deficiencies had a positive effect (p < 0.01) on the calculated HV SDS. When applying the KIGS targets for severe iGHD, mean HV SDS was close to zero (-0.09 +/- 0.84). Conclusion: The developed age-specific growth response curves enable rapid identification of poor response to first-year GH treatment in prepubertal iGHD children. Our results validate the published growth targets derived from the KIGS database. (C) 2014 S. Karger AG, Basel |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Hormone research in paediatrics. - Basel
| |
|
Publication
|
|
|
|
Basel
:
Karger
,
2014
| |
|
ISSN
|
|
|
|
1663-2818
| |
|
DOI
|
|
|
|
10.1159/000358330
| |
|
Volume/pages
|
|
|
|
81
:5
(2014)
, p. 343-349
| |
|
ISI
|
|
|
|
000337797800008
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|