Title
Non-invasive technique for assessment of vascular wall stiffness using laser Doppler vibrometry Non-invasive technique for assessment of vascular wall stiffness using laser Doppler vibrometry
Author
Faculty/Department
Faculty of Sciences. Physics
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Bristol ,
Subject
Physics
Source (journal)
Measurement science and technology. - Bristol
Volume/pages
25(2014) :6 , 10 p.
ISSN
0957-0233
0957-0233
Article Reference
065701
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter is best known when estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery in the groin, but may also be determined locally from short-distance measurements on a short vessel segment. In this work, we propose a novel, non-invasive, non-contact laser Doppler vibrometry (LDV) technique for evaluating PWV locally in an elastic vessel. First, the method was evaluated in a phantom setup using LDV and a reference method. Values correlated significantly between methods (R <= 0.973 (p <= 0.01)); and a Bland-Altman analysis indicated that the mean bias was reasonably small (mean bias <= -2.33 ms). Additionally, PWV was measured locally on the skin surface of the CCA in 14 young healthy volunteers. As a preliminary validation, PWV measured on two locations along the same artery was compared. Local PWV was found to be between 3 and 20 m s(-1), which is in line with the literature (PWV = 5-13 m s(-1)). PWV assessed on two different locations on the same artery correlated significantly (R = 0.684 (p < 0.01)). In summary, we conclude that this new non-contact method is a promising technique to measure local vascular stiffness in a fully non-invasive way, providing new opportunities for clinical diagnosing.
E-info
https://repository.uantwerpen.be/docman/iruaauth/63dfa8/2098025.pdf
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