Publication
Title
In vitro diagnosis of immediate IgE-mediated drug hypersensitivity warnings and (unmet) needs
Author
Abstract
Immediate drug hypersensitivity reactions (DHR) constitute an important health condition, with serious consequences of inadequate diagnosis. In this article, some of the most important issues related to in vitro diagnosis of IgE-mediated allergies are discussed. In vitro diagnostics will benefit from expanded and novel insights and understandings in drug chemical reactivity, protein binding, biotransformation, degradation, identification of (cross-reactive) drug antigenic determinants, and deeper understanding of sensitization routes. Collective efforts should be undertaken to activate fundamental and clinical investigations.
Language
English
Source (journal)
Immunology and allergy clinics of North America. - Philadelphia, Pa
Publication
Philadelphia, Pa : 2014
ISSN
0889-8561
Volume/pages
34:3(2014), p. 681-689
ISI
000339694700016
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 08.09.2014
Last edited 17.07.2017
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