Title
In vitro diagnosis of immediate IgE-mediated drug hypersensitivity warnings and (unmet) needs In vitro diagnosis of immediate IgE-mediated drug hypersensitivity warnings and (unmet) needs
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Philadelphia, Pa ,
Subject
Human medicine
Source (journal)
Immunology and allergy clinics of North America. - Philadelphia, Pa
Volume/pages
34(2014) :3 , p. 681-689
ISSN
0889-8561
ISI
000339694700016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Immediate drug hypersensitivity reactions (DHR) constitute an important health condition, with serious consequences of inadequate diagnosis. In this article, some of the most important issues related to in vitro diagnosis of IgE-mediated allergies are discussed. In vitro diagnostics will benefit from expanded and novel insights and understandings in drug chemical reactivity, protein binding, biotransformation, degradation, identification of (cross-reactive) drug antigenic determinants, and deeper understanding of sensitization routes. Collective efforts should be undertaken to activate fundamental and clinical investigations.
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