Title
Towards a better understanding of **Lactobacillus rhamnosus** GG - host interactions
Author
Faculty/Department
Faculty of Sciences. Bioscience Engineering
Publication type
article
Publication
London ,
Subject
Biology
Engineering sciences. Technology
Source (journal)
Microbial cell factories. - London
Volume/pages
13(2014) :S:1 , 16 p.
ISSN
1475-2859
1475-2859
Article Reference
S7
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Lactobacillus rhamnosus GG (LGG) is one of the most widely used probiotic strains. Various health effects are well documented including the prevention and treatment of gastro-intestinal infections and diarrhea, and stimulation of immune responses that promote vaccination or even prevent certain allergic symptoms. However, not all intervention studies could show a clinical benefit and even for the same conditions, the results are not univocal. Clearly, the host phenotype governed by age, genetics and environmental factors such as the endogenous microbiota, plays a role in whether individuals are responders or non-responders. However, we believe that a detailed knowledge of the bacterial physiology and the LGG molecules that play a key role in its host-interaction capacity is crucial for a better understanding of its potential health benefits. Molecules that were yet identified as important factors governing host interactions include its adhesive pili or fimbriae, its lipoteichoic acid molecules, its major secreted proteins and its galactose-rich exopolysaccharides, as well as specific DNA motifs. Nevertheless, future studies are needed to correlate specific health effects to these molecular effectors in LGG, and also in other probiotic strains.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/aa242a/203f4c49.pdf
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