Publication
Title
Overcoming cetuximab resistance in HNSCC : the role of AURKB and DUSP proteins
Author
Abstract
Unraveling the underlying mechanisms of cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) is of major importance as many tumors remain non-responsive or become resistant. Our microarray results suggest that resistant cells still exhibit RASMAPK pathway signaling contributing to drug resistance, as witnessed by low expression of DUSP5 and DUSP6, negative regulators of ERK1/2, and increased expression of AURKB, a key regulator of mitosis. Therefore, interrupting the RASMAPK pathway by an ERK1/2 inhibitor (apigenin) or an AURKB inhibitor (barasertib) might be a new strategy for overcoming cetuximab resistance in HNSCC.
Language
English
Source (journal)
Cancer letters. - Amsterdam
Publication
Amsterdam : 2014
ISSN
0304-3835
Volume/pages
354:2(2014), p. 365-377
ISI
000344127600018
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 23.09.2014
Last edited 24.04.2017
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