Title
<tex>$GABA_{A}$</tex> receptors predict aversion-related brain responses : an fMRI-PET investigation in healthy humans <tex>$GABA_{A}$</tex> receptors predict aversion-related brain responses : an fMRI-PET investigation in healthy humans
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York, N.Y. ,
Subject
Human medicine
Source (journal)
Neuropsychopharmacology. - New York, N.Y.
Volume/pages
38(2013) :8 , p. 1438-1450
ISSN
0893-133X
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cues are unclear. Based on previous work indicating ventromedial prefrontal cortex (vmPFC) involvement in the mediation of context-dependent emotional effects, we hypothesized a central role for the vmPFC in modulating sensorimotor cortex activity using a GABAergic mechanism during an aversiveaversive stimulus interaction. This approach revealed differential activations within the aversion-related network (eg, sensorimotor cortex, midcingulate, and insula) for the aversiveaversive, when compared with the aversiveneutral, interaction. Individual differences in sensorimotor cortex signal changes during the aversiveaversive interaction were predicted by GABAA receptors in both vmPFC and sensorimotor cortex. Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing.
E-info
https://repository.uantwerpen.be/docman/iruaauth/dcbbd8/97e1b01dbb6.pdf