Publication
Title
Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma
Author
Abstract
While a polymorphism located within the promoter region of the MDM2 proto-oncogene, SNP309 (T > G), has previously been associated with increased risk and aggressiveness of neuroblastoma and other tumor entities, a protective effect has also been reported in certain other cancers. In this study, we evaluated the association of MDM2 SNP309 with outcome in 496 patients with neuroblastoma and its effect on MDM2 expression. No significant difference in overall or event-free survival was observed among patients with neuroblastoma with or without MDM2 SNP309. The presence of SNP309 does not affect MDM2 expression in neuroblastoma. (C) 2014 Wiley Periodicals, Inc.
Language
English
Source (journal)
Pediatric Blood and Cancer. - -
Publication
2014
ISSN
1545-5009
Volume/pages
61:10(2014), p. 1867-1870
ISI
000340541100028
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 09.10.2014
Last edited 10.09.2017
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