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Title
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Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children
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Author
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Abstract
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| Rhinitis and asthma are the most common respiratory diseases in children. We assessed whether airway inflammation markers were associated with nasal allergies and self-reported symptoms of wheeze and rhinitis in 130 children 6-12 year old in an epidemiological context. Independent of sex and age, the fraction of exhaled nitric oxide (FeNO) and nasal mast cell (MC) activation (tryptase >= 5 ng/mL) were positively associated with wheeze, rhinitis and with nasal allergy. Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH, 8-isoprostane, interleukin-1 beta) were not associated with symptoms or with nasal allergy. In conclusion, FeNO and nasal tryptase reflect allergic inflammation in the respiratory system. |
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Language
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English
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Source (journal)
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Biomarkers: biochemical indicators of exposure, response, and susceptibility to chemicals
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Publication
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2014
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ISSN
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1354-750X
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DOI
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10.3109/1354750X.2014.937362
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Volume/pages
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19
:6
(2014)
, p. 481-487
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ISI
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000340768500007
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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