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Title
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Performance of HRP2-based rapid test in children attending the health centre compared to asymptomatic children in the community
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Author
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Abstract
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| Background: The Democratic Republic of the Congo (DRC) is one of the five countries carrying half of global malaria burden with children 0-5 years old being most at risk. Rapid diagnostic tests (RDTs) are currently routinely used for the detection of Plasmodium infection in health centres and may be a useful tool for population-based survey. Methods: This study assessed, in a stable transmission zone of Kinshasa, whether a HRP2-based RDT matches the selection criteria of the National Malaria Control Programme (NMCP), DRC and assessed the most relevant fever threshold in this context. Results: RDTs and microscopy were concordant in 84.3% and 83.4% children in the health centre and at the community level, respectively. The sensitivity was high (>95%), but the specificity was too low and lower in the community (66.9%; 95%CI: 58.5-75.2) compared to the HC (79.4%; 95%CI: 75.7-83.2). The estimated parasitic threshold of 5,414 parasites/mu l was with a sensitivity of 63.3% and a specificity of 71.8% not very discriminative, and thus not a threshold. Conclusion: HRP-based RDT gives a satisfactory proxy to estimate and monitor malaria endemicity, but the low specificity, far below the selection criteria of the NMCP, DRC is problematic for use in a clinical setting. |
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Language
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English
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Source (journal)
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Malaria journal. - London
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Publication
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London
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2014
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ISSN
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1475-2875
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DOI
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10.1186/1475-2875-13-308
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Volume/pages
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13
(2014)
, 8 p.
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Article Reference
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308
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ISI
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000341032300001
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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