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Title
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In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected Guinean plants
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Author
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Abstract
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| Based on an ethnobotanical survey, 41 Guinean plant species widely used in the traditional treatment of fever and/or malariawere collected. From these, 74 polar and apolar extracts were prepared and tested for their in vitro antiprotozoal activity along with their cytotoxicity on MRC-5 cells. A potent activity (IC50 < 5 μg/mL) was observed for Terminalia albida, Vismia guineensis, Spondias mombin, and Pavetta crassipes against Plasmodium falciparum; for Pavetta crassipes, Vismia guineensis, Guiera senegalensis, Spondias mombin, Terminalia macroptera, and Combretum glutinosum against Trypanosoma brucei brucei; for Bridelia ferruginea, G. senegalensis, V. guineensis, P. crassipes, and C. glutinosum against Trypanosoma cruzi. Only the extract of Tetracera alnifolia showed a good activity (IC50 8.1 μg/mL) against Leishmania infantum. The selectivity index of the active samples varied from 0.08 to > 100. These results may validate at least in part the traditional use of some of the plant species. |
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Language
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English
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Source (journal)
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Planta medica: natural products and medicinal plant research. - Stuttgart
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Publication
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Stuttgart
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2014
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ISSN
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0032-0943
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DOI
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10.1055/S-0034-1383047
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Volume/pages
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80
:15
(2014)
, p. 1340-1344
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ISI
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000343124600013
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Pubmed ID
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25180493
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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