Title
In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected Guinean plants In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected Guinean plants
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Stuttgart ,
Subject
Biology
Pharmacology. Therapy
Source (journal)
Planta medica: natural products and medicinal plant research. - Stuttgart
Volume/pages
80(2014) :15 , p. 1340-1344
ISSN
0032-0943
ISI
000343124600013
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Based on an ethnobotanical survey, 41 Guinean plant species widely used in the traditional treatment of fever and/or malariawere collected. From these, 74 polar and apolar extracts were prepared and tested for their in vitro antiprotozoal activity along with their cytotoxicity on MRC-5 cells. A potent activity (IC50 < 5 μg/mL) was observed for Terminalia albida, Vismia guineensis, Spondias mombin, and Pavetta crassipes against Plasmodium falciparum; for Pavetta crassipes, Vismia guineensis, Guiera senegalensis, Spondias mombin, Terminalia macroptera, and Combretum glutinosum against Trypanosoma brucei brucei; for Bridelia ferruginea, G. senegalensis, V. guineensis, P. crassipes, and C. glutinosum against Trypanosoma cruzi. Only the extract of Tetracera alnifolia showed a good activity (IC50 8.1 μg/mL) against Leishmania infantum. The selectivity index of the active samples varied from 0.08 to > 100. These results may validate at least in part the traditional use of some of the plant species.
E-info
https://repository.uantwerpen.be/docman/iruaauth/6dae03/73e8dc65de3.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/11ac11/8800.pdf
https://repository.uantwerpen.be/docman/irua/71fa9d/8801.pdf
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