Title
Sclerosing bone dysplasias : leads toward novel osteoporosis treatments
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Philadelphia, Pa ,
Subject
Human medicine
Source (journal)
Current osteoporosis reports. - Philadelphia, Pa, 2003, currens
Volume/pages
12(2014) :3 , p. 243-251
ISSN
1544-1873
ISI
000347284200001
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Sclerosing bone dysplasias are a group of rare, monogenic disorders characterized by increased bone density resulting from the disturbance in the fragile equilibrium between bone formation and resorption. Over the last decade, major contributions have been made toward better understanding of the pathogenesis of these conditions. These studies provided us with important insights into the bone biology and yielded the identification of numerous drug targets for the prevention and treatment of osteoporosis. Here, we review this heterogeneous group of disorders focusing on their utility in the development of novel osteoporosis therapies.
E-info
https://repository.uantwerpen.be/docman/iruaauth/f84a4f/1869fa8fd16.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/cfbfed/8525.pdf
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Handle