|
Title
|
|
|
|
In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Temporal lobe epilepsy (TLE) is a chronic epileptic disorder involving the hippocampal formation. Details on the interactions between the hippocampus proper and parahippocampal networks during ictogenesis remain, however, unclear. In addition, recent findings have shown that epileptic limbic networks maintained in vitro are paradoxically less responsive than non-epileptic control (NEC) tissue to application of the convulsant drug 4-aminopyridine (4AP). Field potential recordings allowed us to establish here the effects of 4AP in brain slices obtained from NEC and pilocarpine-treated epileptic rats; these slices included the hippocampus and parahippocampal areas such as entorhinal and perirhinal cortices and the amygdala. First, we found that both types of tissue generate epileptiform discharges with similar electrographic characteristics. Further investigation showed that generation of robust ictal-like discharges in the epileptic rat tissue is (i) favored by decreased hippocampal output (ii) reinforced by ECsubiculum interactions and (iii) predominantly driven by amygdala networks. We propose that a functional switch to alternative synaptic routes may promote network hyperexcitability in the epileptic limbic system. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Neurobiology of disease. - San Diego, Calif.
|
|
|
Publication
|
|
|
|
San Diego, Calif.
:
2010
|
|
|
ISSN
|
|
|
|
0969-9961
|
|
|
DOI
|
|
|
|
10.1016/J.NBD.2010.05.003
|
|
|
Volume/pages
|
|
|
|
39
:3
(2010)
, p. 372-380
|
|
|
ISI
|
|
|
|
000280544100016
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|