Title
Laser-evoked potentials as a tool for assessing the efficacy of antinociceptive drugsLaser-evoked potentials as a tool for assessing the efficacy of antinociceptive drugs
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Theoretical neurobiology
Publication type
article
Publication
London,
Subject
Biology
Human medicine
Source (journal)
European journal of pain. - London
Volume/pages
14(2010):2, p. 222-225
ISSN
1090-3801
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Laser-evoked potentials (LEPs) are brain responses to laser radiant heat pulses and reflect the activation of Aδ nociceptors. LEPs are to date the reference standard technique for studying nociceptive pathway function in patients with neuropathic pain. To find out whether LEPs also provide a useful neurophysiological tool for assessing antinociceptive drug efficacy, in this double-blind placebo-controlled study we measured changes induced by the analgesic tramadol on LEPs in 12 healthy subjects. We found that tramadol decreased the amplitude of LEPs, whereas placebo left LEPs unchanged. The opioid antagonist naloxone partially reversed the tramadol-induced LEP amplitude decrease. We conclude that LEPs may be reliably used in clinical practice and research for assessing the efficacy of antinociceptive drugs.