Title
Sustainable three-component synthesis of isothioureas from isocyanides, thiosulfonates, and amines Sustainable three-component synthesis of isothioureas from isocyanides, thiosulfonates, and amines
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
Weinheim ,
Subject
Chemistry
Source (journal)
Angewandte Chemie: international edition in English. - Weinheim
Volume/pages
53(2014) :47 , p. 12849-12854
ISSN
1433-7851
ISI
000344793400031
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Multiple applications of isothioureas as fine chemicals (or their precursors) are known, but a general sustainable method for their synthesis was hitherto unavailable. We report a novel general approach towards S-alkyl and S-aryl isothioureas through a copper(I)-catalyzed three-component reaction between amines, isocyanides, and thiosulfonates. The formal synthesis of a superpotent sweetener further illustrates the applicability of our method.
E-info
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