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Title
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Sustainable three-component synthesis of isothioureas from isocyanides, thiosulfonates, and amines
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Author
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Abstract
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| Multiple applications of isothioureas as fine chemicals (or their precursors) are known, but a general sustainable method for their synthesis was hitherto unavailable. We report a novel general approach towards S-alkyl and S-aryl isothioureas through a copper(I)-catalyzed three-component reaction between amines, isocyanides, and thiosulfonates. The formal synthesis of a superpotent sweetener further illustrates the applicability of our method. |
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Language
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English
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Source (journal)
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Angewandte Chemie: international edition in English. - Weinheim
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Publication
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Weinheim
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2014
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ISSN
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1433-7851
0570-0833
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DOI
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10.1002/ANIE.201406717
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Volume/pages
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53
:47
(2014)
, p. 12849-12854
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ISI
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000344793400031
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Pubmed ID
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25223494
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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