Publication
Title
Sustainable three-component synthesis of isothioureas from isocyanides, thiosulfonates, and amines
Author
Abstract
Multiple applications of isothioureas as fine chemicals (or their precursors) are known, but a general sustainable method for their synthesis was hitherto unavailable. We report a novel general approach towards S-alkyl and S-aryl isothioureas through a copper(I)-catalyzed three-component reaction between amines, isocyanides, and thiosulfonates. The formal synthesis of a superpotent sweetener further illustrates the applicability of our method.
Language
English
Source (journal)
Angewandte Chemie: international edition in English. - Weinheim
Publication
Weinheim : 2014
ISSN
1433-7851
0570-0833
Volume/pages
53:47(2014), p. 12849-12854
ISI
000344793400031
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.11.2014
Last edited 05.09.2017
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