Publication
Title
Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS
Author
Abstract
Hair analysis is a powerful tool for retrospective drug analysis and has a wide application window. This article describes the simultaneous determination and quantification of the short-acting atypical antipsychotic drug quetiapine and its main metabolite 7-OH quetiapine in hair. A sensitive and accurate method for the determination of these two compounds was developed using high-performance liquid chromatography coupled to tandem mass spectrometry detection (LC-MS/MS). The method was applied to 10 real case samples. For five patients, a time resolved hair analysis was done. Results varied from 0.35 ng/mg to 10.21 ng/mg hair for quetiapine and from 0.02 ng/mg to 3.19 ng/mg hair for 7-OH-quetiapine. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Language
English
Source (journal)
Forensic science international. - Lausanne
Publication
Lausanne : 2014
ISSN
0379-0738
Volume/pages
242(2014), p. 200-203
ISI
000342054000037
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 06.11.2014
Last edited 20.06.2017
To cite this reference