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Title
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Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS
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Author
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Abstract
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| Hair analysis is a powerful tool for retrospective drug analysis and has a wide application window. This article describes the simultaneous determination and quantification of the short-acting atypical antipsychotic drug quetiapine and its main metabolite 7-OH quetiapine in hair. A sensitive and accurate method for the determination of these two compounds was developed using high-performance liquid chromatography coupled to tandem mass spectrometry detection (LC-MS/MS). The method was applied to 10 real case samples. For five patients, a time resolved hair analysis was done. Results varied from 0.35 ng/mg to 10.21 ng/mg hair for quetiapine and from 0.02 ng/mg to 3.19 ng/mg hair for 7-OH-quetiapine. (C) 2014 Elsevier Ireland Ltd. All rights reserved. |
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Language
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English
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Source (journal)
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Forensic science international. - Lausanne, 1978, currens
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Publication
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Lausanne
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2014
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ISSN
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0379-0738
[print]
1872-6283
[online]
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DOI
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10.1016/J.FORSCIINT.2014.07.002
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Volume/pages
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242
(2014)
, p. 200-203
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ISI
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000342054000037
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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