Title
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Vernolepin : an antiplatelet compound of natural origin
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Author
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Abstract
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Vernolepin, a natural compound isolated from Vernonia amygdalina Del., shows platelet anti-aggregating properties. In this paper some of its pharmacological activities towards rabbit platelets are studied. Vernolepin has a stabilizing effect during freeze-thawing of platelets, it inhibits arachidonic acid, ADP and collagen-induced platelet aggregation and interferes with ATP-release. Electromicroscopy shows a protection of platelets by the drug against adhesion and a desaggregating effect. All these activities are time dependent; a steep dose response relationship is seen. A concentration of 1×10−5 g/ml seems to be optimal. |
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Language
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English
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Source (journal)
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Naunyn-Schmiedebergs archives of pharmacology. - Berlin
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Publication
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Berlin
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1985
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ISSN
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0028-1298
[print]
1432-1912
[online]
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DOI
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10.1007/BF00498859
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Volume/pages
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331
:1
(1985)
, p. 108-113
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ISI
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A1985ATA5700016
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Full text (Publisher's DOI)
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