Publication
Title
Vernolepin : an antiplatelet compound of natural origin
Author
Abstract
Vernolepin, a natural compound isolated from Vernonia amygdalina Del., shows platelet anti-aggregating properties. In this paper some of its pharmacological activities towards rabbit platelets are studied. Vernolepin has a stabilizing effect during freeze-thawing of platelets, it inhibits arachidonic acid, ADP and collagen-induced platelet aggregation and interferes with ATP-release. Electromicroscopy shows a protection of platelets by the drug against adhesion and a desaggregating effect. All these activities are time dependent; a steep dose response relationship is seen. A concentration of 1×10−5 g/ml seems to be optimal.
Language
English
Source (journal)
Naunyn-Schmiedebergs archives of pharmacology. - Berlin
Publication
Berlin : 1985
ISSN
0028-1298
Volume/pages
331:1(1985), p. 108-113
ISI
A1985ATA5700016
Full text (Publishers DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 18.11.2014
Last edited 28.04.2017
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