Title
Vernolepin : an antiplatelet compound of natural origin Vernolepin : an antiplatelet compound of natural origin
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Berlin ,
Subject
Pharmacology. Therapy
Source (journal)
Naunyn-Schmiedebergs archives of pharmacology. - Berlin
Volume/pages
331(1985) :1 , p. 108-113
ISSN
0028-1298
ISI
A1985ATA5700016
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Vernolepin, a natural compound isolated from Vernonia amygdalina Del., shows platelet anti-aggregating properties. In this paper some of its pharmacological activities towards rabbit platelets are studied. Vernolepin has a stabilizing effect during freeze-thawing of platelets, it inhibits arachidonic acid, ADP and collagen-induced platelet aggregation and interferes with ATP-release. Electromicroscopy shows a protection of platelets by the drug against adhesion and a desaggregating effect. All these activities are time dependent; a steep dose response relationship is seen. A concentration of 1×10−5 g/ml seems to be optimal.
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