Title
Pharmacological influence of nutmeg and nutmeg constituents on rabbit platelet function
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Stuttgart ,
Subject
Biology
Pharmacology. Therapy
Source (journal)
Planta medica: natural products and medicinal plant research. - Stuttgart
Volume/pages
50(1984) :3 , p. 222-226
ISSN
0032-0943
ISI
A1984TC69100005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Pharmacological properties of nutmeg components in relation to prostaglandin biosynthesis were investigated. Only the volatile oil contained the active principles. Several batches of oils showed the same anti-aggregating activity on rabbit platelets aggregated with arachidonic acid (AA). The most active products present in nutmeg oil were eugenol and isoeugenol. These aromatic ethers were equipotent to indomethacin. Other active products, in decreasing order of potency, were the aromatic ethers safrole, myristicin and elemicin, the monoterpene hydrocarbon limonene, and the monoterpene alcohols α-terpineol, terpinene-4-ol and linalool. The major monoterpene hydrocarbons including α- and β-pinene and camphene however, which constitute the oil for about 50%, were inactive.
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