|
Title
|
|
|
|
Plant antiviral agents : 5 : 3-methoxyflavones as potent inhibitors of viral induced block of cell synthesis
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| An investigation of the constituents responsible for the pronounced antiviral activity observed for extracts of Euphorbia grantii Oliv. stems has afforded four related 3-methoxyflavones exhibiting remarkable activities against picornaviruses and vesicular stomatitis virus. All compounds were found to be derivatives of 3-methylquercetin. The concentration of 3-methylquercetin (3-MQ) and 3,3′-dimethyl-quercetin (3,3′-DMQ) inhibiting 90 % of polio type 1 and coxsackie B4 viruses in tissue culture was about 0.01 µg/ml, whereas the 50 % cytotoxic concentration was 40 µg/ml. When administered intraperitoneally, 3-MQ protected mice from viremia and lethal infections from coxsac kie B4 virus at a daily dose of 20 mg/kg for a period of nine days. Biochemical studies on the mechanism of action of 3-MQ or 3,3′-DMQ on poliovirus replication suggested that these 3-methoxyflavones are able to protect the host cells from a viral induced shutdown of the cellular protein synthesis. Preliminary structure activity relationship studies have shown the 3-methoxyfunction of the flavones to be essential for the observed antiviral effects. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Planta medica: natural products and medicinal plant research. - Stuttgart
|
|
|
Publication
|
|
|
|
Stuttgart
:
1984
|
|
|
ISSN
|
|
|
|
0032-0943
|
|
|
DOI
|
|
|
|
10.1055/S-2007-969786
|
|
|
Volume/pages
|
|
|
|
50
:6
(1984)
, p. 513-517
|
|
|
ISI
|
|
|
|
A1984TX53800015
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|