Title
Plant antiviral agents : 5 : 3-methoxyflavones as potent inhibitors of viral induced block of cell synthesis Plant antiviral agents : 5 : 3-methoxyflavones as potent inhibitors of viral induced block of cell synthesis
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Stuttgart ,
Subject
Biology
Pharmacology. Therapy
Source (journal)
Planta medica: natural products and medicinal plant research. - Stuttgart
Volume/pages
50(1984) :6 , p. 513-517
ISSN
0032-0943
ISI
A1984TX53800015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
An investigation of the constituents responsible for the pronounced antiviral activity observed for extracts of Euphorbia grantii Oliv. stems has afforded four related 3-methoxyflavones exhibiting remarkable activities against picornaviruses and vesicular stomatitis virus. All compounds were found to be derivatives of 3-methylquercetin. The concentration of 3-methylquercetin (3-MQ) and 3,3′-dimethyl-quercetin (3,3′-DMQ) inhibiting 90 % of polio type 1 and coxsackie B4 viruses in tissue culture was about 0.01 µg/ml, whereas the 50 % cytotoxic concentration was 40 µg/ml. When administered intraperitoneally, 3-MQ protected mice from viremia and lethal infections from coxsac kie B4 virus at a daily dose of 20 mg/kg for a period of nine days. Biochemical studies on the mechanism of action of 3-MQ or 3,3′-DMQ on poliovirus replication suggested that these 3-methoxyflavones are able to protect the host cells from a viral induced shutdown of the cellular protein synthesis. Preliminary structure activity relationship studies have shown the 3-methoxyfunction of the flavones to be essential for the observed antiviral effects.
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