Title
A case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndromeA case of recurrent non-small-cell lung carcinoma and paraneoplastic Cushing's syndrome
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam,
Subject
Human medicine
Source (journal)
Lung cancer: journal of the International Association for the Study of Lung Cancer / International Association for the Study of Lung Cancer [Aurora, Colo.] - Amsterdam
Volume/pages
51(2006):2, p. 251-255
ISSN
0169-5002
ISI
000235564000013
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Secretion of ectopic adrenocorticotropic hormone (ACTH) with consequently Cushing's syndrome is a rare paraneoplastic phenomenon. It has been described in a variety of malignancies, like bronchial carcinoids, small-cell lung carcinoma, thymoma, pancreatic carcinoma and other. In many cases of suspected ectopic ACTH secretion, it is difficult to histologically or cytochemically confirm the diagnosis. We present a 63-year-old woman with a recurrent poorly differentiated squamous cell lung carcinoma with clinical and biochemical features consistent with ectopic Cushing's syndrome. Immunocytochemical staining confirmed the secretion of ACTH by tumour cells. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
E-info
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