Title
Hypofractionated external beam radiotherapy as retreatment for symptomatic non-small-cell lung carcinoma : an effective treatment? Hypofractionated external beam radiotherapy as retreatment for symptomatic non-small-cell lung carcinoma : an effective treatment?
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Bedford ,
Subject
Human medicine
Computer. Automation
Source (journal)
International journal of radiation oncology, biology, physics. - Bedford
Volume/pages
58(2004) :5 , p. 1388-1393
ISSN
0360-3016
ISI
000220533000009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Purpose: To evaluate prospectively the efficacy, toxicity, and duration of the palliative effect of retreatment with external beam radiotherapy in symptomatic patients with recurrent non-small-cell lung cancer. Methods and Materials: Twenty-eight symptomatic patients with local recurrence of non-small-cell lung cancer underwent repeated treatment after previous radiotherapy (equivalent dose, 46-60 Gy). Reirradiation consisted of two fractions of 8 Gy on Days 1 and 8 with two opposed beams using 6-18-MV photon beams at the site of pulmonary recurrence. The physician scored symptom resolution. Results: Relief of hemoptysis and superior vena cava syndrome could be obtained in all assessable cases (100%). Treatment was less effective for coughing (67%) and dyspnea (35%). The overall median duration of this palliative effect was 4 months. Palliation in almost all patients lasted more than one-half of their remaining life span. The Karnofsky performance score improved in 45% of assessable cases. One patient had Grade 2 esophagitis. Complications consisted of tumor-related fatal hemoptysis in 5 patients (17%) and 1 death from bronchoesophageal fistula (4%). Conclusion: External beam hypofractionated reirradiation can be effective as a palliative treatment for local complaints in non-small-cell lung cancer. The complication rate of reirradiation was acceptably low. (C) 2004 Elsevier Inc.
E-info
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