Title
Fatal outcome of a hypersensitivity reaction to paclitaxel : a critical review of premedication regimens Fatal outcome of a hypersensitivity reaction to paclitaxel : a critical review of premedication regimens
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
The British journal of cancer. - London
Volume/pages
90(2004) :2 , p. 304-305
ISSN
0007-0920
ISI
000189010600005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Hypersensitivity reactions (HSRs) to paclitaxel are frequently encountered in patients receiving this antitumour drug. Administration of histamine H1- and H2-receptor antagonists and corticosteroids has been shown to reduce significantly the risk of developing an HSR in patients receiving taxanes. In this case report, we describe the fatal outcome of an HSR in a patient receiving paclitaxel despite short-course premedication. the level of evidence supporting the short-course i.v. premedication schedule is challenged, as it is not compatible with the pharmacokinetic properties of dexamethasone.
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