Title
Prognostic factors in patients with pleural mesothelioma : the European Organization for Research and Treatment of Cancer experiencePrognostic factors in patients with pleural mesothelioma : the European Organization for Research and Treatment of Cancer experience
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
New York,
Subject
Human medicine
Source (journal)
Journal of clinical oncology. - New York
Volume/pages
16(1998):1, p. 145-152
ISSN
0732-183X
ISI
000071368500023
Carrier
E
Target language
English (eng)
Abstract
Purpose: Identification of prognostic factors in patients with malignant pleural mesothelioma based on prospectively collected international data. Patients and Methods: From October 1984 to October 1993, 204 eligible adult patients with malignant pleural mesothelioma were entered into five consecutive prospective European Organization for Research and Treatment of Cancer (EORTC) phase II clinical trials designed to assess the efficacy of various anticancer drugs (mitoxantrone, epidoxorubicin, etoposide, and paclitaxel). The Cox model war used to assess 13 factors related to biology and disease history with respect to survival. Results: The median survival duration was 12.6 months from diagnosis and 8.4 months from trial entry, In the multivariate analysis, poor prognosis was associated with a poor performance status, a high WBC count, a probable/possible histologic diagnosis of mesothelioma, male gender, and having sarcomatous tissue as the histologic subtype. Taking these five factors into consideration, patients were classified into two groups: a good-prognosis group (1-year survival rate, 40%; 95% confidence interval [CI], 30% to 50%) and a poor-prognosis group (1-year survival, 12%; 95% CI, 4% to 20%). Conclusion: These results may help to design new clinical trials in pleural mesothelioma by selecting more homogenous groups of patients. (C) 1998 by American Society of Clinical Oncology.
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