Publication
Title
Cellular and molecular neuropathology of the cuprizone mouse model : clinical relevance for multiple sclerosis
Author
Abstract
The cuprizone mouse model allows the investigation of the complex molecular mechanisms behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is generally accepted that oligodendrocytes are specifically vulnerable to cuprizone intoxication due to their high metabolic demands, a comprehensive overview of the etiology of cuprizone-induced pathology is still missing to date. In this review we extensively describe the physico-chemical mode of action of cuprizone and discuss the molecular and enzymatic mechanisms by which cuprizone induces metabolic stress, oligodendrocyte apoptosis, myelin degeneration and eventually axonal and neuronal pathology. In addition, we describe the dual effector function of the immune system which tightly controls demyelination by effective induction of oligodendrocyte apoptosis, but in contrast also paves the way for fast and efficient remyelination by the secretion of neurotrophic factors and the clearance of cellular and myelinic debris. Finally, we discuss the many clinical symptoms that can be observed following cuprizone treatment, and how these strengthened the cuprizone model as a useful tool to study human multiple sclerosis, schizophrenia and epilepsy.
Language
English
Source (journal)
Neuroscience and biobehavioral reviews. - Fayetteville, N. Y, 1978, currens
Publication
Fayetteville, N. Y : ANKHO International Inc, 2014
ISSN
0149-7634
Volume/pages
47(2014), p. 485-505
ISI
000347498900032
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Imaging of Neuroinflammation in Neurodegenerative Diseases (INMIND).
Neural Stem Cells: molecular and physiological control of in vivo migration and differentiation.
Characterisation of innate immune responses in the central nervous system: modulation towards immunological acceptance of allogeneic cellular grafts.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 27.11.2014
Last edited 02.12.2017
To cite this reference