Title
Cellular and molecular neuropathology of the cuprizone mouse model : clinical relevance for multiple sclerosis Cellular and molecular neuropathology of the cuprizone mouse model : clinical relevance for multiple sclerosis
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Fayetteville, N. Y :ANKHO International Inc ,
Subject
Psychology
Biology
Human medicine
Source (journal)
Neuroscience and biobehavioral reviews. - Fayetteville, N. Y, 1978, currens
Volume/pages
47(2014) , p. 485-505
ISSN
0149-7634
ISI
000347498900032
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The cuprizone mouse model allows the investigation of the complex molecular mechanisms behind nonautoimmune-mediated demyelination and spontaneous remyelination. While it is generally accepted that oligodendrocytes are specifically vulnerable to cuprizone intoxication due to their high metabolic demands, a comprehensive overview of the etiology of cuprizone-induced pathology is still missing to date. In this review we extensively describe the physico-chemical mode of action of cuprizone and discuss the molecular and enzymatic mechanisms by which cuprizone induces metabolic stress, oligodendrocyte apoptosis, myelin degeneration and eventually axonal and neuronal pathology. In addition, we describe the dual effector function of the immune system which tightly controls demyelination by effective induction of oligodendrocyte apoptosis, but in contrast also paves the way for fast and efficient remyelination by the secretion of neurotrophic factors and the clearance of cellular and myelinic debris. Finally, we discuss the many clinical symptoms that can be observed following cuprizone treatment, and how these strengthened the cuprizone model as a useful tool to study human multiple sclerosis, schizophrenia and epilepsy.
E-info
https://repository.uantwerpen.be/docman/iruaauth/24b437/4e755a9eba7.pdf
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